Dose-dependent maximal inhibition of DPP-4 ranging from 64% to 92% was observed 2–4 h post dose. 214 In a single-dose study of PHX1149 at 50, 100, 200, 300, or 500 mg in healthy male subjects after an overnight fast, mean drug AUC increased in a dose-proportional manner with a median T max of 2–4 h. 214, 215 PK and PD studies indicate that PHX1149 inhibits DPP-4 enzymatic activity across preclinical species in a time- and dose-dependent manner. Dutogliptin is a highly water-soluble (> 2 g mL − 1) DPP-4 inhibitor with 15- to 319-fold selectivity over other members of the DPP family and a DPP-4 IC 50 of 25 nM. SinhaRoy, in Comprehensive Medicinal Chemistry III, 2017 7.14.5.2.1 Dutogliptin (PHX1149, Phenomix Corp)ĭutogliptin (PHX1149) 127 is a boronic acid-based DPP-4 inhibitor.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |